(PDF) Levels of human replication factor C4, a clamp
Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer.pdf Available via license: CC BY 4.0 Content may be subject
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Identification of key candidate genes and small molecule
Sep 13, 2018 · Xiang J, Fang L, Luo Y, et al. Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer. J Transl Med. 2014;12:320. 44. Mine KL, Shulzhenko N, Yambartsev A, et al. Gene network reconstruction reveals cell cycle and antiviral genes as major drivers of cervical cancer.
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Mechanism of Proliferating Cell Nuclear Antigen Clamp
The eukaryotic replication factor C (RFC) clamp loader is an AAA+ spiral-shaped heteropentamer that opens and closes the circular proliferating cell nuclear antigen (PCNA) clamp processivity factor on DNA. In this study, we examined the roles of individual RFC subunits in opening the PCNA clamp. Interestingly, Rfc1, which occupies the position analogous to the δ clamp-opening subunit in the
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Identification of DNA repair-related genes predicting
Jan 30, 2021 · Xiang J, Fang L, Luo Y, et al. Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer. J Transl Med. 2014;12:320. Article Google Scholar 28.
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Mechanism of Sliding Clamp Loading by the Escherichia coli
While the DNA sequences encoding sliding clamps and clamp loaders are quite different between organisms, the structure and function of these proteins are well conserved (Fig 1 2 3) (Reviewed in (93, 106) ). In eukaryotes, the replication clamp loader is replication factor C (RFC) and the sliding clamp is proliferating cell nuclear antigen (PCNA).
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Structure of the human clamp loader reveals an
The human clamp loader replication factor C (RFC) and sliding clamp proliferating cell nuclear antigen (PCNA) are both essential and play critical roles in several diseases. De-spite decades of study, no structure of human RFC has been re-solved. Here, we report the structure of human RFC bound to
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Arabidopsis replication factor C4 is critical for DNA
Human and yeast cells utilize alternative clamp loaders to carry out specific clamp‐related functions apart from DNA replication. The three clamp loaders, RAD24–RFC (RAD17–RFC in human), CTF18–RFC and ELG1–RFC, are responsible for DNA damage response, sister chromatid adhesion and genome stability, respectively (Kelch, 2016 ).
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Identification of DNA repair-related genes predicting
Jan 30, 2021 · Xiang J, Fang L, Luo Y, et al. Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer. J Transl Med. 2014;12:320. Article Google Scholar 28.
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:: JBC :: Journal of Breast Cancer
Xiang J, Fang L, Luo Y, Yang Z, Liao Y, Cui J, et al. Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer. J …
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Levels of human replication factor C4, a clamp loader
Background: Human replication factor C4 (RFC4) is involved in DNA replication as a clamp loader and is aberrantly regulated across a range of cancers. The current study aimed to investigate the function of RFC4 in colorectal cancer (CRC).
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Levels of human replication factor C4, a clamp loader
Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer By CGA Network, Y Luo, NY Yao, A Johnson, T Oku, T Tsurimoto, T Tsurimoto, HS Kim, SA Krause, E Erdogan, BY Kang, G Narayan, RJ Slebos, XJ Fan, ML Mayer, P Kanellis, WW Lockwood, S Xiong, M Arai, SE Corrette
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Systematic identification of key genes and pathways in the
Jun 30, 2017 · Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer J. Transl. Med., 12 ( 1 ) ( 2014 ), pp. 1 - 11 CrossRef View Record in Scopus Google Scholar
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The reconstituted human Chl12‐RFC complex functions as a
Apr 02, 2004 · The sister chromatid cohesion factor Chl12 shares amino acid sequence similarity with RFC1, the largest subunit of replication factor C (RFC), and forms a clamp loader complex in association with the RFC small subunits RFCs2‐5.
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The PCNA–RFC Families of DNA Clamps and Clamp Loaders
ating cell nuclear antigen) and PCNA-interacting proteins, its associated clamp loader RFC (replication factor C), and related clamps and clamp loaders important for such disparate functions as the DNA damage checkpoint and the establishment of chromatid cohesion in …
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Replication Factor C4 in human hepatocellular carcinoma: A
Replication Factor c4 (RFC4) has been found to play important roles in many carcinomas and is correlated with poor prognosis. The present study was performed to investigate the specific role of RFC4 in hepatocellular carcinoma (HCC) and the underlying molecular mechanism. Public datasets including TCGA and GTEx were applied to explore the expression of RFC4 in HCC and its association with HCC
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Levels of human replication factor C4, a clamp loader
Nov 19, 2014 · Human replication factor C4 (RFC4) is involved in DNA replication as a clamp loader and is aberrantly regulated across a range of cancers. The current study aimed to investigate the function of RFC4 in colorectal cancer (CRC).
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Levels of human replication factor C4, a clamp loader
Levels of human replication factor C4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer By Jun Xiang, Lekun Fang, Yanxin Luo, Zuli Yang, Yi Liao, Ji Cui, Meijin Huang, Zihuan Yang, Yan Huang, Xinjuan Fan, Huashe Wang, …
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Key Genes and Signaling Pathways in Small Cell Lung Cancer
[23] Xiang J, Fang L, Luo Y, et al. Levels of human replication factor c4, a clamp loader, correlate with tumor progression and predict the prognosis for colorectal cancer[J].
Get a quoteReplication Factor C - an overview | ScienceDirect Topics
Replication Factor C. RFC, the eukaryotic clamp loader, is a five-subunit complex of 140-, 40-, 38-, 37-, and 36-kDa proteins (for Rfc1–5, respectively). All five subunits are essential for cell viability and all belong to the AAA+ family of ATPases. In addition to the conserved domains found in all members of this family, the large subunit
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Structure of the human clamp loader reveals an
The sliding clamp needs to be opened and installed onto DNA by a clamp loader ATPase of the AAA+ family. The human clamp loader … DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles DNA, where it acts as an essential …
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